Frances Valesco (born 1941) is an artist, printmaker, muralist, and educator. She focuses on visual metaphors, and the connection between nature and activism. She travels to artist residencies in many parts of the world. She finds herself moved by and influenced by those landscapes. Her works evolve from places where nature triggers an emotional response.  She is inspired by John Muir, whose activism saved Yosemite Valley in California. "I only went out for a walk and finally concluded to stay out till sundown, for going out, I found, was really going in."

Frances has been described as a pollinator of cultural expression. She is a community builder, representing a variety of voices. She is one of the first muralists to benefit from the Comprehensive Employment and Training Act (CETA) arts program. Making murals and fine art prints, she is known for creating cooperative and integrative projects.

Among her thirty murals are the Desert Mural, Kool Blue. El Torneo entre el Sol y el Viento is in Balmy Alley, San Francisco. It is designated as part of the Calle 24 Latino Cultural District. One of her most enduring and long-standing projects is the Disability Mural.  It is located at the Ed Roberts Campus in Berkeley, CA, where she served as a founder and coordinator.